Search results for "Steroid hormone receptor"

showing 6 items of 6 documents

Coordinates in the Universe of Node-Negative Breast Cancer Revisited

2009

Abstract We present a global picture of the natural history of node-negative breast cancer in which two of three important biological processes have outstanding prognostic consequences. We propose that the transition from slow to fast proliferation of the tumor leads to the most dramatic aggravation of prognosis. Second, immune cell infiltration is of major importance to prevent disease progression in fast-proliferating breast carcinomas, regardless of estrogen receptor status. In the absence of endocrine treatment, steroid hormone receptor expression as a third axis is of limited prognostic importance. Dissecting tumors according to these three major biological axes will allow further unde…

CA15-3Cancer ResearchPathologymedicine.medical_specialtySteroid hormone receptorbusiness.industryCancerBreast Neoplasmsmedicine.diseaseBreast cancerOncologyTumor progressionLymphatic MetastasismedicineCancer researchHumansEndocrine systemFemaleLymph NodesBreast diseasebusinessEstrogen Receptor StatusCancer Research
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Zum Steroidhormonrezeptorenstatus kolorektaler Karzinome

1990

Zur Analyse des Steroidhormonrezeptorenstatus kolorektaler Karzinome wurde der Ostrogen- und Progesteronrezeptorgehalt von 26 aufeinanderfolgenden Tumoren bestimmt. In alien Proben lag die Estradiol-Rezeptorbindungskapazitat unterhalb des mestechnischen Cut-offs von 2 fmol/mg Cytosolprotein. In 4 von 26 Tumorproben (15%) waren Progesteron-Rezeptorspiegel zwischen 13 und 23 fmol/ mg Cytosolprotein nachweisbar. Aufgrund des Nachweises von Stero-idhormonrezeptoren in einigen Fallen und vereinzelter Berichte in der Literatur uber Remissionen unter Hormontherapie kolorektaler Karzinome scheinen weitere In-vitro- und In-vivo-Versuche angezeigt, die Hormonabhangigkeit des kolorektalen Karzinoms zu…

GynecologyCancer Researchmedicine.medical_specialtyOncologySteroid hormone receptorbusiness.industrymedicineHematologybusinessOncology Research and Treatment
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Steroid hormone receptor analysis in human melanoma and non-malignant human skin

1982

MaleReceptors SteroidSkin NeoplasmsSteroid hormone receptorbusiness.industryReceptors Cell SurfaceNon malignantHuman skinDermatologyReceptors GlucocorticoidReceptors EstrogenImmunologyCancer researchHumansMedicineFemaleHuman melanomaProgestinsbusinessMelanomaSkinBritish Journal of Dermatology
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Relation of elastosis to biochemical and immunohistochemical steroid receptor findings, Ki-67 and epidermal growth factor receptor (EGFR) immunostain…

1993

We studied 1073 cases of invasive ductal breast cancer, NOS for their elastic content (DEL, ductal+periductal elastosis; TEL, tumour elastosis) and compared the findings with the results of biochemical and immunohistochemical steroid hormone receptor examination. Tumours of patients up to 50 years of age and older were examined separately. In a number of tumours elastosis was also examined in relation to Ki-67 and epidermal growth factor receptor (EGFR) immunostaining. Sensitivity and specificity of DEL and TEL for predicting the receptor, Ki-67 and EGFR findings were estimated. Sensitivity of DEL and TEL for oestrogen and progesterone receptors is dependent on the degree of tumour differen…

Pathologymedicine.medical_specialtySteroid hormone receptorMammary glandBreast NeoplasmsBiologySensitivity and SpecificityPathology and Forensic MedicineBreast cancerEpidermal growth factormedicineHumansEpidermal growth factor receptorConnective Tissue DiseasesMolecular BiologyEpitheliomaNuclear ProteinsCell BiologyGeneral MedicineMiddle Agedmedicine.diseaseNeoplasm ProteinsErbB ReceptorsReceptors Antigenmedicine.anatomical_structureCarcinoma Intraductal NoninfiltratingKi-67 AntigenKi-67biology.proteinImmunohistochemistryFemaleVirchows Archiv. A, Pathological anatomy and histopathology
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The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two re…

1995

AbstractPeroxisome proliferators (PPs) are non-genotoxic carcinogens in rodents. They can induce the expression of numerous genes via the heterodimerization of two members of the steroid hormone receptor superfamily, called the peroxisome proliferator-activated receptor (PPAR) and the 9-cis retinoic acid receptor (RXR). Many of the PP responsive genes possess a peroxisome proliferator response element (PPRE) formed by two TGACCT-related motifs. The bifunctional enzyme (HD) PPRE contains 3 such motifs, creating DR1 and DR2 sequences. PPAR and RXR regulate transcription via the DR1 element while DR2 modulates the expression of the gene via auxiliary factors in HepG2 cells.

Peroxisome proliferator-activated receptor gammaReceptors Retinoic AcidSteroid hormone receptorMolecular Sequence DataResponse elementBiophysicsReceptors Cytoplasmic and NuclearPeroxisome proliferator-activated receptorchemical and pharmacologic phenomenaIn Vitro TechniquesRegulatory Sequences Nucleic AcidRetinoid X receptorBiologyPeroxisomal Bifunctional EnzymeTransfectionMicrobodiesBiochemistryGene Expression Regulation EnzymologicTranscriptional activationPeroxisomal Bifunctional EnzymeMultienzyme ComplexesStructural BiologyPeroxisome proliferator response element9-cis Retinoic acid receptor alphaTumor Cells CulturedGeneticsHumansRNA MessengerIsomerasesEnoyl-CoA HydrataseMolecular Biologychemistry.chemical_classificationBinding SitesBase Sequence3-Hydroxyacyl CoA DehydrogenasesPeroxisome proliferator-activated receptorCell BiologyDNA-Binding ProteinsRetinoic acid receptorRetinoid X ReceptorsLiverOligodeoxyribonucleotidesBiochemistrychemistryRat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenaseEnzyme InductionPeroxisome proliferator-activated receptor alphaTranscription FactorsFEBS Letters
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Intratumoral Heterogeneity for hsp90β mRNA Levels in a Breast Cancer Cell Line

1997

BC-3A and BC-61 are two breast cancer cell lines that have been cloned from parental 8701-BC cells and exhibit different biosynthetic, proliferative, and invasive properties in vitro. In the attempt to search whether alterations in the profiles of gene expression could be detected, we have submitted both cytotypes to identification of differentially expressed cDNAs. In addition, steroid hormone receptor mRNA arrays and in vivo tumorigenesis of the two lines have been checked. The technique used allowed identification of changes in the expression of the 90-kD heat shock protein-beta (hsp90beta) which is prominently down-regulated in BC-61 cells. Because we have also found that these cells, w…

Steroid hormone receptorMice NudeEstrogen receptorBreast NeoplasmsBiologymedicine.disease_causeMiceBreast cancerIn vivoHeat shock proteinGene expressionTumor Cells CulturedGeneticsmedicineAnimalsHumansHSP90 Heat-Shock ProteinsRNA MessengerRNA NeoplasmMolecular BiologyDNA NeoplasmCell BiologyGeneral Medicinemedicine.diseaseMolecular biologyIn vitroGene Expression Regulation NeoplasticReceptors EstrogenReceptors ProgesteroneCarcinogenesisDNA and Cell Biology
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